After a goalless first half, Danny Batth headed Wolves into the lead on 67 minutes. Donovan Wilson then sealed victory in the dying minutes, finishing smartly over Fraser Forster to send the travelling Wolves fans wild.
Speaking after the game, Nuno said: “It was very good, very good for the boys.
“We’re through. We came here to fight against a tough team, a Premier League team.
“That motivation plus discipline, plus organisation gave us a very good victory.
“There were 11 changes but this result shows that there is no ‘starting XI’ at Wolves.
“There is a Wolves squad that prepares and works hard every day and they got a deserved prize today.
“They showed character, they showed quality and were able to compete against a very good team.
“The boys are really pleased. Especially the young ones, the Under 23s that came with us.
“They should be proud because the work they did today was really, really important for us.”
When asked how it felt to beat a Premier League side in Southampton, the Head Coach responded: “Beating Southampton is the same value as beating Yeovil in Round One.
“We’re through. That was our goal. In the Carabao Cup we will go for as long as we can, fight and compete.
“We are happy. The boys were fantastic today and I’m very proud.
“There were players coming back from injury, players who haven’t played in a long time and there were youngsters.
“It gives us good signs going forward. Besides the team, we want to build a really big club, a strong club. Back to the Wolves of the 50s and 60s.”
The Head Coach was quick to turn attention to the work that the staff and players are continuing to do at the training ground and highlighted that Wolves are still very much a 'work in progress'.
“We are building on a daily basis,” explained Nuno before adding: “We are growing. And when you are growing the real challenge is to maintain these performances between Tuesdays and Saturdays.
“We have the league, then the Carabao Cup and soon we will have the FA Cup – these are all challenges for us.
“That shows the way that the players are getting into the new ideas.
“They work every day and that gives us the sensation that they are really committing to our ideas and convictions.
“Organisation and discipline mixed with talent gets you success.
“But the most important thing is how the players perform on the pitch.”